综合改进奇异谱分解和奇异值分解的齿轮故障特征提取方法

针对齿轮故障特征微弱，在强背景噪声下难以有效提取的问题，提出了一种改进奇异谱分解（ISSD）结合奇异值分解（SVD）的齿轮故障特征提取方法。针对奇异谱分解（SSD）算法中模态参数需凭经验选取的缺陷，基于散布熵优化算法对SSD算法进行了改进，在得到既定的一组奇异谱分量的基础上，根据峭度值最大准则筛选出了最佳奇异谱分量并进行了SVD处理，采用奇异值能量标准谱自适应地确定了信号重构阶数以还原信号和提高降噪效果。最后对信号进行包络解调以提取齿轮故障特征，将所提方法运用到仿真信号和齿轮实测信号中，并同传统包络谱、SSD包络谱以及经验模态分解结合SVD(EMD-SVD)方法进行了对比分析，结果表明，所提方法的降噪和特征提取效果更佳，能够更加有效地实现齿轮故障的判别。     

基于特征贡献率的机械故障分类方法

为了使7075铝合金薄壁件表面喷丸加工应力得到松弛和均化，运用ANSYS建立平台式振动时效有限元模型，通过振动模态和谐响应分析，获得最佳激振频率和试样装夹位置。在此基础上，将薄壁框架件置于平台上进行振动时效处理，以验证仿真分析结果，评价其对试样表面应力作用效果。结果表明：在亚共振频率为112 Hz时，试样在平台零振幅和最大弯曲位置处分别对称布置，时效后表面均形成应力松弛，松弛率分别为29.5%和33.3%，不均匀波动分别为20.3%和20.7%，而沿振动方向松弛程度不均匀，说明激振力造成了材料表面组织屈服，且屈服程度与应力强度有关。提出再时效-位置交叠方法，使应力松弛不均匀度分别下降到9.9%和15.9%，应力均化得到改善，该研究工作为薄壁类零件表面应力均匀化提供了参考。     

掘进巷道快速过断层施工技术应用

基于四候煤矿3108回风顺槽过F3断层期间,顶板出现严重破碎、下沉现象,提出了俯斜台阶法施工工艺,并对断层破碎带顶板采取MF-2型化学材料注浆加固以及"钢筋锚索网+U29梯形棚"联合支护措施。支护效果检验结果表明,联合支护有效控制了断层破碎区顶板下沉、破碎现象,保证了巷道顶板稳定性。     

二甲双胍联合糖皮质激素治疗伴糖耐量异常的系统性红斑狼疮患者的临床研究

目的: 探究二甲双胍联合糖皮质激素治疗伴糖耐量异常(IGT)的系统性红斑狼疮(SLE)患者的临床疗效及对胰岛功能、Th17/Treg细胞失衡的影响。方法: 本院84例伴IGT的SLE患者随机分为联用组和对照组各42例,均给予生活、饮食指导,对照组给予糖皮质激素治疗,联用组联合二甲双胍治疗,1个月后观察疗效,并评估胰岛功能和Th17/Treg细胞失衡情况。结果: 联用组总有效率明显高于对照组(90.48% vs. 71.43%,P<0.05),SLE活动指数评分为(2.6±0.3)分,红细胞沉降率(ESR)为(18±4)mm/h,显著低于对照组的(3.9±0.8)分、(23±4)mm/h(P<0.05)。治疗后联用组空腹血糖(FBG)、空腹胰岛素(Fins)、稳态模型-胰岛素抵抗指数(HOMA-IR)、胰岛β功能细胞指数(HOMA-β)显著改善(P<0.05),且与对照组相比差异有统计学意义(P<0.05);联用组正常糖耐量(NGT)占比明显高于对照组(73.81% vs. 30.95%,P<0.05)。治疗后联用组Th17、Treg细胞比例为(6.2±0.9)个/μL、(31±7)个/μL,Th17/Treg为(0.20±0.05),与对照组的(7.4±1.3)个/μL、(28±7)个/μL、(0.26±0.06)相比有统计学差异(P<0.05)。治疗后SLE活动指数评分与HOMA-IR、HOMA-β及Th17细胞、Treg细胞、Th17/Treg明显相关(P<0.05),且HOMA-IR、HOMA-β与Th17细胞、Treg细胞、Th17/Treg也明显相关(P<0.05)。2组不良反应均轻微,发生率无统计学差异(P>0.05)。结论: 二甲双胍联合糖皮质激素治疗伴IGT的SLE患者疗效显著,可控制疾病活动性,降低血糖水平、改善胰岛功能及纠正Th17/Treg细胞失衡,且安全性高。     

Nanostructured lipid carriers based nanogel for meloxicam delivery: mechanistic,in-vivo and stability evaluation

Aim: Our investigation was aimed to investigate the potential suitability of meloxicam-loaded nanostructured lipid carriers (MLX-NLC) gel for topical application.

Main methods: MLX-NLC gel was prepared and in vivo skin penetration ability of the NLC gel was evaluated using confocal laser scanning microscopy. We studied the effect of MLX-NLC gel on the changes in lipid profile of skin to get an insight into its skin penetration enhancement mechanism. Acetic acid induced writhing test was performed to evaluate the analgesic effect. Drug concentration-time profile of MLX in rat plasma and skin after topical and oral treatment with MLX-NLC gel and oral MLX-solution, respectively, was observed. MLX-NLC gel was subjected to primary skin irritation test, sub-acute dermal toxicity study. Storage stability of MLX-NLC gel was also assessed for 90 days.

Key findings: NLC gel was effective in permeating Rhodamine 123 to deeper layers of rat skin. Changes in skin lipid prolife were observed in the rat skin on treatment with MLX-NLC gel and the results supported skin lipid extraction as a possible penetration enhancement mechanism. MLX-NLC gel demonstrated sustained pain inhibitory effect. Pharmacokinetics study established that topical application of MLX-NLC gel had the potential to avoid systemic uptake and hence the risk of systemic adverse effects. MLX-NLC gel demonstrated good skin tolerability and biosafety. Excellent physical stability of nanogel was observed at 4?±?2?°C.

Significance: The study revealed that NLC gel is a promising carrier system for the topical application of MLX without side effects.     

Fault estimation and accommodation for networked control systems with nonuniform sampling periods

This paper deals with the problem of fault estimation and accommodation for a class of networked control systems with nonuniform uncertain sampling periods. Firstly, the reason why the adaptive fault diagnosis observer cannot be applied to networked control systems is analyzed. Based on this analysis, a novel robust fault estimation observer is constructed to estimate both continuous‐time fault and system states by using nonuniformly discrete‐time sampled outputs. Furthermore, using the obtained states and fault information, a nonuniformly sampled‐data fault tolerant control law is designed to preserve the stability of the closed‐loop system. The proposed scheme can not only guarantee the impact of continuous‐time uncertainties and discrete‐time sampled estimation errors on the faulty system to satisfy a H _∞ performance index but also repress the negative effect of the unknown intersample behavior of continuous‐time fault by use of an inequality technique. Finally, simulation results are included to demonstrate the feasibility of the proposed method. Copyright © 2014 John Wiley & Sons, Ltd.     

胶东三山岛西岭金矿区NW向断裂带的确定：综合物探证据

三山岛西岭金矿区位于渤海之滨，与北部海域金矿区相互连接，形成金资源量近千吨的巨型金矿床，矿床为地下与海底开采。区域内断裂发育，分布有NE向和NW向断裂，其中NE向断裂为控矿构造，而NW向断裂多具有不同程度的导水性，对矿床安全开采影响重大。基于矿区地质条件与地球物理特征，采用高精度磁测法和音频大地电磁（AMT）法在矿区东部进行了勘查试验，根据显示的磁性异常与电性异常，在平面上解译了NW向断裂(F-1、F-2)与NE向断裂（F-3、F-4），在L1剖面上解译了4条断裂，在L2剖面上解译了3条断裂。综合判断解译信息，NW向F-1断裂在平面与剖面上都反映良好。同时，与北部海域NW向构造研究资料进行对比分析，结果显示西岭矿区F-1推断断层与北部海域B-F4断层特征一致，吻合较好，推断西岭矿区NW向F-2断裂被F-3断裂错断。研究结果说明综合物探方法在该区域可行有效，为下一步钻孔验证NW向断裂存在，判断断裂富水及导水性质，以及未来矿床开发利用提供了地球物理依据。     

Parallel quality-related dynamic principal component regression method for chemical process monitoring

Traditional quality-related process monitoring mainly focuses on the magnitude change of the quality variables caused by additive faults. However, the abnormal fluctuations in the quality variables caused by multiplicative faults are often overlooked. In this paper, a novel parallel dynamic principal component regression (P-DPCR) algorithm is proposed to monitor the changes in the magnitude and fluctuation of the quality variables simultaneously. Firstly, in order to eliminate the interference of quality-unrelated variables, the quality-related process variables are selected on the basis of correlation analysis. Secondly, the dynamic extension and moving window are carried out for process variables and quality variables, in which the dynamic variables space (called X-space/Y-space) and the variance space (called VX-space/VY-space) are constructed. Afterwards, double quality-related statistics based on the regression model of these four spaces are given, and the comprehensive monitoring decision can be obtained. Finally, two numerical cases and the Tennessee Eastman process are used to show the effectiveness of the proposed method.     

具有双通道数据包丢失的Delta算子系统故障检测

研究同时存在双通道数据包丢失和时变时延的Delta算子网络控制系统（NCSs）故障检测问题.假定数据包丢失发生在控制器到执行器、传感器至控制器的数据传输过程中，并且利用两个相互独立的伯努利随机变量描述是否发生丢包.将上述的NCSs建模为网络切换系统，提出任意切换律下故障检测滤波器的设计方法.利用线性矩阵不等式（LMIs）方法、Lyapunov-Krasovskii泛函和平均驻留时间等得出所考虑的网络切换系统具备指数均方稳定性的充分条件.证明了所用的网络切换系统满足H_∞性能，并推导出了滤波器参数的显式表达.数值仿真结果验证了所提方法的有效性.     

基于变异测试的错误定位研究进展

随着软件规模和复杂度的不断提高，软件的质量问题成为了关注的焦点，如何高效地找出软件中的错误成为一个亟需解决的问题。错误定位是软件质量保证的重要途径之一，近年来已经成为软件工程中一个非常重要的研究课题。基于变异测试的错误定位通过比较原程序和对应变异体的差异来计算每条语句的怀疑度，再由怀疑度大小进行排序，程序员根据排序逐个检查找出错误语句。汇总近7年（2012-2018）国内外的基于变异测试的错误定位技术的研究成果，介绍了错误定位的基本方法，介绍基于变异测试的错误定位思想，从变异算子、变异体及等价变异体3个方面对已有的研究工作进行分类归纳和总结，探讨了基于变异测试的错误定位未来可能的研究方向、机遇和挑战。